A Normal Inhibitor of the Blood Coagulation Contact Reaction Product

A Normal Inhibitor of the Blood Coagulation Contact Reaction Product.

2 - Glycoprotein I : A Plasma Inhibitor of the Contact Activation of the Intrinsic Blood Coagulation Pathway

The general hypothesis for the biological function of 112W glycoprotein I is that it neutralizes all negatively charged macromolecules that might enter the bloodstream and diminishes unwanted activation of the blood coagulation. In the present study we report that $2-glycoprotein I inhibits the activation of the contact phase system of the intrinsic pathway of blood coagulation. Activation was ...

Preparation of 'contact product' as a reagent for coagulation tests.

A renaissance for the contact system in blood coagulation?

Thromb Haemost 2008; 99: 457–460 Anumber of recent studies call for a reevaluation in our perception of the role of the contact activation system in blood coagulation. The antithrombotic phenotype of factor (F) XII-knockout mice and the identification of RNA and polyphosphates as physiological surfaces for contact activation provide new evidence that the contact system contributes to blood coag...

Reaction-diffusion waves of blood coagulation.

One of the main characteristics of blood coagulation is the speed of clot growth. In the current work we consider a mathematical model of the coagulation cascade and study existence, stability and speed of propagation of the reaction-diffusion waves of blood coagulation. We also develop a simplified one-equation model that reflects the main features of the thrombin wave propagation. For this eq...